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This can be a bone infection

Bone and joint infections are a relatively rare occurrence.

However their prompt diagnosis and treatment is important to improve healing and reduce damage to tissues and organs.


A painful joint or limb may be related to a local infection.


Classical signs and symptoms of infection, like

  • Pain
  • Redness
  • Warmth
  • Swelling
  • Stiffness
  • Fever

may not always be present and sometimes they can be mild or occasional.


If a persistent pain around a joint or a limb segment is present, you should consult your physician.



Peri-Prosthetic Infection Diagnosis

Diagnosis of peri-prosthetic infection (infection of hip or knee or other joint prosthesis) often requires multiple tests and should be performed in specialized Centers.


Diagnosis is based on:

- History of the Patient;

- Clinical examination;

- Laboratory tests;

- Joint aspiration and cultural examination (when possible);

- Imaging techniques.






a New Patented System to Find Bacteria on Removed Prosthetic Implants


Since bacteria that colonize a prosthesis or other implants (and even bone) are protected by biofilms, their detection becomes particularly difficult.


New technologies are now available to dislodge bacteria from biofilms to allow better microbiological analysis and diagnosis.


microDTTect is a new medical device, that allows to collect samples intra-operatively and process them with a chemical compounds, dithiotreithol (DTT).


DTT has been demonstrated highly efficient in removeing bacteria from biofilms and hence allow better diagnosis and bacteria isolation from retrieved samples.


Microbiological diagnosis is a key factor in driving treatment and to select the most appropriate antibiotic therapy. 


This is the reason why DTT has been recently inserted in the official guidelines of the Italian Microbiological Society as the method of choice to process retrieved implant in orthopaedics and trauma. 


Peri-Prosthetic Infection Diagnosis - Bone and Joint Infections

Joint Aspiration and New Diagnostic Tests for PJIs

Joint Aspiration and New Diagnostic Tests for PJIs - Bone and Joint Infections

Peri-prosthetic infection (PJI) may be associated with an increased joint fluid production.


Joint fluid, also known as "sinovial fluid", can be collected by the surgeon through a relatively simple procedure, that can be performed on an ooutpatient basis, in the medical office: Joint Aspiration.


The aspirated fluid can be processed to diagnose an infection around the prosthesis.


Synovial fluid markers are available in the best centers to accurately diagnose peri-prosthetic joint infections, according to a recent algorithm.



Joint aspiration should be done according to a strictly aseptic procedure and by trained orthopaedic surgeons.



SINOVIASURE: an important help for the rapid diagnosis of PJIs

SINOVIASURE: an important help for the rapid diagnosis of PJIs - Bone and Joint Infections

Prof. Carlo L. Romanò was the first in Europe to use the Sinoviasure test to diagnose PJIs.

Bone and Joint Infections

Galeazzi Institute - Milano - Italy

Bone and Joint Infections


Bone and Joint Infections

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